A brief introduction to multi-stage trials for developing dynamic treatment regimens

Abstract

There is growing interest in developing evidence-based sequences of treatment which are able to adapt to an individual’s changing needs over time. In this talk, I introduce dynamic treatment regimens, which seek to operationalize clinical practice in the sense that they provide a set of individualized treatment recommendations, and sequential multiple-assignment randomized trials, which help scientists answer questions about dynamic treatment regimens. The talk is aimed at a clinical audience, and uses an example from the field of alcohol use disorder.

Nicholas J. Seewald

Assistant Professor of Biostatistics

Assistant Professor of Biostatistics at the University of Pennsyvlania Perelman School of Medicine