masters

Design and Analysis Considerations for Comparing Dynamic Treatment Regimens with Binary Outcomes from Sequential Multiple Assignment Randomized Trials
In behavioral, educational and medical practice, interventions are often personalized over time using strategies that are based on …
Kelley M. Kidwell, Nicholas J. Seewald, Qui Tran, Connie Kasari, Daniel Almirall
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Prospective Assessment of Patient-Reported Outcomes and Estradiol and Drug Concentrations in Patients Experiencing Toxicity from Adjuvant Aromatase Inhibitors

Purpose. Aromatase inhibitors (AI), which decrease circulating estradiol concentrations in post-menopausal women, are associated with …

Kunal C. Kadakia, Kelley M. Kidwell, Nicholas J. Seewald, Claire F. Snyder, Anna Maria Storniolo, Julie L. Otte, David A. Flockhart, Daniel F. Hayes, Vered Stearns, N. Lynn Henry
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Sequential Multiple Assignment Randomized Trials: An Opportunity for Improved Design of Stroke Reperfusion Trials

BACKGROUND: Modern clinical trials in stroke reperfusion fall into 2 categories: alternative systemic pharmacological regimens to …

William J. Meurer, Nicholas J. Seewald, Kelley Kidwell
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Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women with Early Stage Breast Cancer

BACKGROUND. Early discontinuation of aromatase inhibitors (AIs) is common and leads to poor outcomes but is challenging to predict. In …

Kunal C. Kadakia, Claire F. Snyder, Kelley M. Kidwell, Nicholas J. Seewald, David A. Flockhart, Todd C. Skaar, Zereunesay Desta, James M. Rae", Julie L. Otte, Janet S. Carpenter, Anna M. Storniolo, Daniel F. Hayes, Vered Stearns, N. Lynn Henry
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Evidence for Association of SNPs in ABCB1 and CBR3, but Not RAC2, NCF4, SLC28A3 or TOP2B, with Chronic Cardiotoxicity in a Cohort of Breast Cancer Patients Treated with Anthracyclines
AIMS: Validation of associations for SNPs in RAC2, NCF4 and SLC28A3, identification of a novel association with a TOP2B SNP and …
Daniel L. Hertz, Megan V. Caram, Kelley M. Kidwell, Jacklyn N. Thibert, Christina Gersch, Nicholas J. Seewald, Jeffrey Smerage, Melvyn Rubenfire, N. Lynn Henry, Kathleen A. Cooney, Monika Leja, Jennifer J. Griggs, James M. Rae"
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Polymorphisms in Drug-Metabolizing Enzymes and Steady-State Exemestane Concentration in Postmenopausal Patients with Breast Cancer
Discovery of clinical and genetic predictors of exemestane pharmacokinetics was attempted in 246 postmenopausal patients with breast …
Daniel L. Hertz, Kelley M. Kidwell, Nicholas J. Seewald, Christina L. Gersch, Zeruesenay Desta, David A. Flockhart, Ana-Maria Storniolo, Vered Stearns, Todd C. Skaar, Daniel F. Hayes, N. Lynn Henry, James M. Rae"
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Design, analysis, and sizing of sequential multiple assignment randomized trials with binary outcomes
A 45-minute invited presentation on SMARTs with binary outcomes for the U-M Department of Statistics’ Graduate Student Seminar.
Sep 24, 2015 12:00 PM — 1:00 PM University of Michigan, Ann Arbor, MI, USA
Nicholas J. Seewald, Daniel Almirall, Kelley M. Kidwell
Slides
Design, analysis, and sizing of sequential multiple assignment randomized trials with binary outcomes
A SMART web-based sample size calculator
A poster at the Michigan Student Symposium for Interdisciplinary Statistical Sciences. Winner, Best Departmental Poster Award, Biostatistics.
Mar 20, 2015 10:15 AM — 11:15 AM University of Michigan, Ann Arbor, MI, USA
Nicholas J. Seewald, Daniel Almirall, Kelley M. Kidwell
Project Poster
A SMART web-based sample size calculator