cancer

Patient-Reported Outcomes in Cancer

Patient-centered care is an important aspect of treating cancer, particularly as a way to inform comparative effectiveness research. This work builds an evidence base for treatment selection based on quality of life and other measures.

Cancer Biomarkers and Pharmacogenomics

A series of collaborations with cancer researchers at the University of Pennsylvania and the University of Michigan investigating associations between biomarkers, genes, tumor morphology, and outcomes.

Corticosteroid-dependent association between prognostic peripheral blood cell-free DNA levels and neutrophil-mediated NETosis in patients with glioblastoma

Purpose: Non-invasive prognostic biomarkers to inform clinical decision-making are an urgent unmet need for the management of patients …

Jacob E. Till, Nicholas J. Seewald, Zachariya Yazdani, Zhuoyang Wang, Dominique Ballinger, Heather Samberg, Siri Dandu, Camilla Macia, Melinda Yin, Aseel Abdalla, Timothy Prior, Shivani Shah, Thara Patel, Emily McCoy, Maikel Monsour, Carson A. Wills, Veronica Bochenek, Jonathan Serrano, Matija Snuderl, Richard E. Phillips, Donald M. O’Rourke, Nduka M. Amankulor, Ali Nabavizadeh, Arati S. Desai, Kandace Gollomp, Zev A. Binder, Wanding Zhou, Stephen J. Bagley, Erica L. Carpenter

[Abstract] Real-world time on treatment (rwTOT) with first-line (1L) enfortumab vedotin and pembrolizumab (EV+P) after U.S. Food and Drug Administration approval for advanced urothelial cancer (aUC)

ASCO Meeting Abstract from the 2025 ASCO Genitourinary Cancers Symposium

Melanie Mayer, Nicholas J. Seewald, Ernesto Ulloa Perez, Blanca Homet Moreno, Chethan Ramamurthy, Aram Babcock, Haojie Li, Ronac Mamtani

[Abstract] Does liver tumor morphology predict outcomes after LDT, PRRT or captem?

Background: Patients with metastatic neuroendocrine tumor (NET) have multiple options for liver-directed therapy (LDT) and systemic …

Cathal O'Leary, David Tischfield, Rony Avritscher, Ghassan El-Haddad, Nicholas Fidelman, Ricardo Garcia-Monaco, Nimrata Vijayvergia, Pamela Kunz, Nicholas J. Seewald, Michael C. Soulen

[Abstract] LODESTAR: A Single Arm Phase II Study of Rucaparib in Solid Tumors with Pathogenic Germline or Somatic Variants in Homologous Recombination Repair (HRR) Genes

Purpose: Poly (ADP-ribose) polymerase inhibitors (PARPi) have proven clinical utility in platinum-sensitive breast, ovary, pancreas, …

Sriram Anbil, Nicholas J. Seewald, Kevin Lin, Marcia Craib, Christy Connor, Heidi Giordano, Karen McLachlan, Tanya Kwan, Lara Maloney, Hanna Tukachinsky, Alexa Schrock, Shuoguo Wang, Ethan Sokol, Brennan Decker, Katherine Nathanson, Susan Domchek, Kim Reiss

[Abstract] Association of BRCA1/2 pathogenic variants with primary tumor location and metastatic organotropism in pancreatic adenocarcinoma

Background: Pancreatic cancers (PDACs) with BRCA1/2 pathogenic variants (PVs) are prognostically favorable and predict response to …

Ryan Hood, Srishti Rathore, Nicholas J. Seewald, Kim Anna Reiss

[Abstract] Interaction of BRCA1 vs BRCA2 pathogenic variants with primary tumor location in pancreatic cancer

Background: BRCA1/2 germline or somatic pathogenic variants (PVs) are found in 5-10% of pancreatic adenocarcinoma (PDAC) patients. …

Ryan Hood, Nicholas J. Seewald, Srishti Rathore, Kim Anna Reiss

Prospective Assessment of Patient-Reported Outcomes and Estradiol and Drug Concentrations in Patients Experiencing Toxicity from Adjuvant Aromatase Inhibitors

Purpose. Aromatase inhibitors (AI), which decrease circulating estradiol concentrations in post-menopausal women, are associated with …

Kunal C. Kadakia, Kelley M. Kidwell, Nicholas J. Seewald, Claire F. Snyder, Anna Maria Storniolo, Julie L. Otte, David A. Flockhart, Daniel F. Hayes, Vered Stearns, N. Lynn Henry

Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women with Early Stage Breast Cancer

BACKGROUND. Early discontinuation of aromatase inhibitors (AIs) is common and leads to poor outcomes but is challenging to predict. In …

Kunal C. Kadakia, Claire F. Snyder, Kelley M. Kidwell, Nicholas J. Seewald, David A. Flockhart, Todd C. Skaar, Zereunesay Desta, James M. Rae", Julie L. Otte, Janet S. Carpenter, Anna M. Storniolo, Daniel F. Hayes, Vered Stearns, N. Lynn Henry