DTRs

A Brief Introduction to Multi-Stage Trials for Developing Dynamic Treatment Regimens

A 1-hour seminar on dynamic treatment regimens (DTRs) and sequential multiple-assignment randomized trials geared towards a clinical audience.

Building Effective Adaptive Interventions in Mental Health Services Research

The Johns Hopkins ALACRITY Center for Health and Longevity in Mental Illness hosts trainings for researchers interested in methods used in health services research. This series of videos provides an introduction to the use of SMARTs to build high-quality adaptive interventions for health services.

A Brief Introduction to Multi-Stage Trials for Developing Dynamic Treatment Regimens

There is growing interest in developing evidence-based sequences of treatment which are able to adapt to an individual's changing needs over time. In this talk, I introduce dynamic treatment regimens, which seek to operationalize clinical practice in …

Sequential, Multiple Assignment, Randomized Trials (SMART)

A dynamic treatment regimen (DTR) is a prespecified set of decision rules that can be used to guide important clinical decisions about treatment planning. This includes decisions concerning how to begin treatment based on a patient’s characteristics …

Sample Size and Timepoint Tradeoffs for Comparing Dynamic Treatment Regimens in a Longitudinal SMART

Clinical practice often involves delivering a sequence of treatments which adapts to a patient’s changing needs. A dynamic treatment regimen (DTR) is a sequence of pre-specified decision rules which, based on a patient’s ongoing data, recommend …

Sample Size Considerations for Comparing Dynamic Treatment Regimens in a Sequential Multiple-Assignment Randomized Trial with a Continuous Longitudinal Outcome

Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a sequence of prespecified decision rules which can be used to guide the delivery of a sequence of treatments or …

Design and Analysis Considerations for Comparing Dynamic Treatment Regimens with Binary Outcomes from Sequential Multiple Assignment Randomized Trials

In behavioral, educational and medical practice, interventions are often personalized over time using strategies that are based on individual behaviors and characteristics and changes in symptoms, severity, or adherence that are a result of one's …