Article-Journal

Plasma cell-free DNA markers predict occult metastases in patients with resectable pancreatic ductal adenocarcinoma
Jacob E. Till, Ofer Gal-Rosenberg, Sophia G. Giliberto, Nicholas J. Seewald, Dominique Ballinger, Heather E. Samberg, Melinda R. Yin, Qiao-Li Wang, Samuele Cannas, Kristine N. Kim, Kyle Tien, Mohammed Sawi, Vidya Madineedi, C. Sloane Furniss, Vasilena Gocheva, Jonathan Nowak, Lauren K. Brais, Chen Yuan, Michael H. Rosenthal, Robert Roses, Ronald DeMatteo, Major Kenneth Lee, Chrles Vollmer, Hersh Sagreiya, Mark H. O'Hara, Ruth Shemer, Brian Wolpin, Yuval Dor, Erica L. Carpenter
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The Impact of Medicaid Expansion on HIV Pre-Exposure Prophylaxis Coverage
Although its availability has grown during the past decade, pre-exposure prophylaxis (PrEP) remains underused in the US. We evaluated …
Elizabeth M. Stone, Nicholas J. Seewald, Joseph G. Rosen
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The impact of medical cannabis laws on cannabis and opioid use disorder treatment and overdose-related healthcare utilization among adults with chronic non-cancer pain

Context: State medical cannabis laws, currently in place in 39 states and Washington, DC, provide an avenue for therapeutic use of …

Emma E. McGinty, Pradyhumna Wagle, Christie Lee Luo, Nicholas J. Seewald, Elizabeth A. Stuart, Kayla N. Tormohlen
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The impact of implementing a standardized protocol for labor induction on obstetric disparities: secondary analysis of a type I hybrid effectiveness-implementation trial

Introduction: Prior retrospective data demonstrated that standardization of labor induction may reduce racial disparities in cesarean …

Rebecca F. Hamm, Sunni L. Mumford, Markolline Forkpa, Nicholas J. Seewald, Rinad S. Beidas, Sindhu K. Srinivas, Samuel Parry, Lisa D. Levine
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LODESTAR: A single arm phase II study of rucaparib in solid tumors with pathogenic germline or somatic variants in homologous recombination repair genes

Purpose: To explore PARP inhibitor (PARPi) utility across solid tumors and identify biomarkers that predict sensitivity.

Patients and …

Sriram Anbil, Nicholas J. Seewald, E. Gabriela Chiorean, Maen Hussein, Pashtoon Murtaza Kasi, Doug E. Laux, Gary K. Schwartz, Geoffrey Shapiro, Kevin K. Lin, Marcia Craib, Lara Maloney, Karen McLachlan, Hanna Tukachinsky, Alexa B. Schrock, Shuoguo Wang, Ethan S. Sokol, Brennan Decker, Katherine L. Nathanson, Susan M. Domchek, Kim A. Reiss
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Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units
A collaborative paper led my MSCE student Emily Moin, MD. Following pandemic-era changes, many ICU outcome measures returned to prior levels. The rates of mechanical ventilation have declined even further, while vasopressor use remained elevated above 2010s rates.
Emily E. Moin, Nicholas J. Seewald, Scott D. Halpern
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Corticosteroid-dependent association between prognostic peripheral blood cell-free DNA levels and neutrophil-mediated NETosis in patients with glioblastoma

Purpose: Non-invasive prognostic biomarkers to inform clinical decision-making are an urgent unmet need for the management of patients …

Jacob E. Till, Nicholas J. Seewald, Zachariya Yazdani, Zhuoyang Wang, Dominique Ballinger, Heather Samberg, Siri Dandu, Camilla Macia, Melinda Yin, Aseel Abdalla, Timothy Prior, Shivani Shah, Thara Patel, Emily McCoy, Maikel Monsour, Carson A. Wills, Veronica Bochenek, Jonathan Serrano, Matija Snuderl, Richard E. Phillips, Donald M. O’Rourke, Nduka M. Amankulor, Ali Nabavizadeh, Arati S. Desai, Kandace Gollomp, Zev A. Binder, Wanding Zhou, Stephen J. Bagley, Erica L. Carpenter
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Target Trial Emulation for Evaluating Health Policy
Target trial emulation is an approach to designing rigorous nonexperimental studies by “emulating” key features of a clinical trial. …
Nicholas J. Seewald, Emma E. McGinty, Elizabeth A. Stuart
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Target Trial Emulation for Evaluating Health Policy
Effects of Texas State Agency Integration on Mental Health Service Use Among Individuals with Co-occurring Cognitive Disabilities and Mental Health Conditions
This study uses Texas’s 2017 integration of the state disability and mental health agencies as a case study, combining interviews with …
Elizabeth M. Stone, Andrew D. Jopson, Nicholas J. Seewald, Elizabeth A. Stuart, Elizabeth Wise, Alexander D. McCourt, Danielle German, Emma E. McGinty
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Effects of U.S. State Medical Cannabis Laws on Treatment of Chronic Noncancer Pain
Background: State medical cannabis laws may lead patients with chronic noncancer pain to substitute cannabis in place of prescription …
Emma E. McGinty, Kayla N. Tormohlen, Nicholas J. Seewald, Mark C. Bicket, Alexander D. McCourt, Lainie Rutkow, Sarah A. White, Elizabeth A. Stuart
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Effects of U.S. State Medical Cannabis Laws on Treatment of Chronic Noncancer Pain