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Adaptive Interventions for a Dynamic and Responsive Public Health Approach

A comment on Wang and Chakraborty (2023) in which I argue that adaptive interventions have the potential to lead us towards a vision of …

Nicholas J. Seewald

Adaptive Interventions for a Dynamic and Responsive Public Health Approach

Scaling Interventions to Manage Chronic Disease: Innovative Methods at the Intersection of Health Policy Research and Implementation Science

Policy implementation is a key component of scaling effective chronic disease prevention and management interventions. Policy can …

Emma E. McGinty, Nicholas J. Seewald, Sachini Bandara, Magdalena Cerdá, Gail L. Daumit, Matthew D. Eisenberg, Beth Ann Griffin, Tak Igusa, John W. Jackson, Alene Kennedy‑Hendricks, Jill Marsteller, Edward J. Miech, Jonathan Purtle, Ian Schmid, Megan S. Schuler, Christina T. Yuan, Elizabeth A. Stuart

Effects of State Opioid Prescribing Laws on Use of Opioid and Other Pain Treatments Among Commercially Insured U.S. Adults

Background: There is concern that state laws to curb opioid prescribing may adversely affect patients with chronic noncancer pain, but …

Emma E. McGinty, Mark C. Bicket, Nicholas J. Seewald, Elizabeth A. Stuart, G. Caleb Alexander, Colleen L. Barry, Alexander D. McCourt

Sample Size Considerations for Comparing Dynamic Treatment Regimens in a Sequential Multiple-Assignment Randomized Trial with a Continuous Longitudinal Outcome

Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a …

Nicholas J. Seewald, Kelley M. Kidwell, Inbal Nahum-Shani, Tianshuang Wu, James R. McKay, Daniel Almirall

Practical Considerations for Data Collection and Management in Mobile Health Micro-Randomized Trials

There is a growing interest in leveraging the prevalence of mobile technology to improve health by delivering momentary, contextualized …

Nicholas J. Seewald, Shawna N. Smith, Andy Jinseok Lee, Predrag Klasnja, Susan A. Murphy

Design and Analysis Considerations for Comparing Dynamic Treatment Regimens with Binary Outcomes from Sequential Multiple Assignment Randomized Trials

In behavioral, educational and medical practice, interventions are often personalized over time using strategies that are based on …

Kelley M. Kidwell, Nicholas J. Seewald, Qui Tran, Connie Kasari, Daniel Almirall

Efficacy of Contextually Tailored Suggestions for Physical Activity: A Micro-Randomized Optimization Trial of HeartSteps

BACKGROUND: HeartSteps is an mHealth intervention that encourages regular walking via activity suggestions tailored to the …

Predrag Klasnja, Shawna Smith, Nicholas J Seewald, Andy Lee, Kelly Hall, Brook Luers, Eric B Hekler, Susan A Murphy

Prospective Assessment of Patient-Reported Outcomes and Estradiol and Drug Concentrations in Patients Experiencing Toxicity from Adjuvant Aromatase Inhibitors

Purpose Aromatase inhibitors (AI), which decrease circulating estradiol concentrations in post-menopausal women, are associated with …

Kunal C. Kadakia, Kelley M. Kidwell, Nicholas J. Seewald, Claire F. Snyder, Anna Maria Storniolo, Julie L. Otte, David A. Flockhart, Daniel F. Hayes, Vered Stearns, N. Lynn Henry

Sequential Multiple Assignment Randomized Trials: An Opportunity for Improved Design of Stroke Reperfusion Trials

BACKGROUND: Modern clinical trials in stroke reperfusion fall into 2 categories: alternative systemic pharmacological regimens to …

William J. Meurer, Nicholas J. Seewald, Kelley Kidwell

Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women with Early Stage Breast Cancer

BACKGROUND Early discontinuation of aromatase inhibitors (AIs) is common and leads to poor outcomes but is challenging to predict. In …

Kunal C. Kadakia, Claire F. Snyder, Kelley M. Kidwell, Nicholas J. Seewald, David A. Flockhart, Todd C. Skaar, Zereunesay Desta, James M. Rae, Julie L. Otte, Janet S. Carpenter, Anna M. Storniolo, Daniel F. Hayes, Vered Stearns, N. Lynn Henry